The Singapore Research Ethics Conference, to be held virtually on 23-25 November 2021, is jointly organised by the National Healthcare Group, National University of Singapore and Singapore Health Services Pte Ltd. This year theme is on "Navigating Ethical and Regulatory Challenges in the New Era for Human Subject Research", with the aims to discuss a wide variety of hot topics relevant to human subject research and to build consensus in key areas of research ethics by promoting knowledge sharing and best practices. The featured topics include Digital Health research, medical device research, patient centric approach in conduct of research and biobanking.